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Term of the Day

Biological Reference Interval


Use: Medical laboratories; Medicine; Medical diagnosis; Medical analysis

Source: ISO 15189:2012

Explanation:

Specified interval of the distribution of values from a biological reference population

Note 1: A reference interval is commonly defined as the central 95% interval. Another size or an asymmetrical location of the reference interval could be more appropriate in particular cases.

Note 2: A reference interval can depend upon the type of primary samples and the examination procedure used.

Note 3: In some cases, only one biological reference limit is important, for example, an upper limit, x, so that the corresponding biological reference interval would be less than or equal to x.

Note 4: Terms such as “normal range”, “normal values”, and “clinical range” are ambiguous and therefore discouraged.